Application of PK/PD modeling in veterinary field: dose optimization and drug resistance prediction

I Ahmad, L Huang, H Hao, P Sanders… - BioMed research …, 2016 - Wiley Online Library
Among veterinary drugs, antibiotics are frequently used. The true mean of antibiotic
treatment is to administer dose of drug that will have enough high possibility of attaining the …

A facile and efficient voltammetric sensor for marbofloxacin detection based on zirconium-based metal-organic framework UiO-66/nitrogen-doped graphene …

T Wang, Y Xia, X Wan, Y Zhang, N Chen, Y Jin… - Microchemical Journal, 2024 - Elsevier
Improper and persistent use of marbofloxacin (MAR) is prone to produce residues that
deteriorate the surrounding environment and endanger our health. Hence, it is urgent to …

Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration

E Terzi, O Corum, S Bilen, ON Kenanoglu, O Atik… - Aquaculture, 2020 - Elsevier
The pharmacokinetics of danofloxacin was studied in rainbow trout (Oncorhynchus mykiss)
after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a …

Pharmacokinetic/pharmacodynamic integration of marbofloxacin after oral and intravenous administration in rainbow trout (Oncorhynchus mykiss)

O Corum, E Terzi, DD Corum, ON Kenanoglu, S Bilen… - Aquaculture, 2020 - Elsevier
The pharmaco-kinetic/dynamic of marbofloxacin was investigated after single intravenous
(IV) and oral administration of 10 mg/kg in 192 healthy rainbow trout at 13±1.2° C. The …

Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations

O Corum, D Durna Corum, A Er, E Terzi… - Food Additives & …, 2018 - Taylor & Francis
Plasma and muscle pharmacokinetics of danofloxacin were investigated after 10 mg/kg
intravenous (IV, caudal vein) and intramuscular (IM, right epaxial muscles) administrations in …

Impact of timing and dosage of a fluoroquinolone treatment on the microbiological, pathological, and clinical outcomes of calves challenged with Mannheimia …

G Lhermie, AA Ferran, S Assié, H Cassard… - Frontiers in …, 2016 - frontiersin.org
The efficacy of an early and low inoculum-adjusted marbofloxacin treatment was evaluated
on microbiological and clinical outcomes in calves infected with 4.107 CFU of Mannheimia …

Comparison of PK/PD Targets and Cutoff Values for Danofloxacin Against Pasteurella multocida and Haemophilus parasuis in Piglets

YF Zhou, Z Sun, RL Wang, JG Li, CY Niu… - Frontiers in Veterinary …, 2022 - frontiersin.org
Danofloxacin is a synthetic fluoroquinolone with broad-spectrum activity developed for use
in veterinary medicine. The aim of this study was to evaluate the pharmacokinetic …

Pharmacokinetic/pharmacodynamic assessment of cefquinome against Actinobacillus Pleuropneumoniae in a piglet tissue cage infection model

L Zhang, X Wu, Z Huang, N Zhang, Y Wu, Q Cai… - Veterinary …, 2018 - Elsevier
To evaluate the relationship between the pharmacokinetic/pharmacodynamic (PK/PD)
parameters and the antibacterial effect of cefquinome against Actinobacillus …

Simultaneous screening for marbofloxacin and ofloxacin residues in animal-derived foods using an indirect competitive immunoassay

X Chen, Z Li, J Guo, D Li, H Gao… - Food and Agricultural …, 2017 - Taylor & Francis
ABSTRACT A broad-specificity immunoassay was established to monitor marbofloxacin
(MBF) and ofloxacin (OFX) residues in raw milk and porcine muscle samples. The main …

In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves

C Cao, Y Qu, M Sun, Z Qiu, X Huang, B Huai… - Frontiers in …, 2015 - frontiersin.org
Marbofloxacin is a fluoroquinolone specially developed for use in veterinary medicine with
broad-spectrum antibacterial activity. The objective of our study was to re-evaluate in vivo …