IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across
the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of …

Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean
clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …

Starting about 60 years ago, a number of reports appeared that outlined the severe clinical
course of a few adult subjects with profound hypogammaglobinemia. Puzzled by the lack of …

Background Diagnostic delay in common variable immunodeficiency disorders (CVID) is
considerable. There is no generally accepted symptom-recognition framework for its early …

Common variable immunodeficiency (CVID), the most common symptomatic primary
antibody deficiency, is accompanied in some patients by a duodenal inflammation and …

OBJECTIVES: Common variable immunodeficiency (CVID) is associated with a spectrum of
autoimmune complications. We studied the prevalence of gastrointestinal (GI) …

Seronegative coeliac disease is a rare condition that accounts for a very small percentage of
cases in the large population of coeliac patients. Strict criteria for the diagnosis of this …

Introduction Patients with common variable immunodeficiency (CVID) have a high frequency
of inflammatory complications like autoimmune cytopenias, interstitial lung disease and …

Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency
(PID) in adulthood and is characterized by severe reduction of immunoglobulin serum levels …