Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent
progress made in molecular genetic studies of osteosarcoma has changed our view on the …

Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Simple Summary Osteosarcomas are heterogeneous bone tumors with complex genetic and
chromosomic alterations. The numerous patients with metastatic osteosarcoma have a very …

Osteosarcoma is the most common primary malignant bone tumor in children and young
adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin …

Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent
populations. It has high metastatic potential, with the lungs being the most common site of …

Objective Accumulating data show that dysregulation of long noncoding RNA s (lnc RNA s)
acts a critical role in a variety of malignancies. Among these lnc RNA s, small nucleolar RNA …

Uncontrolled growth and an enforced epithelial-mesenchymal transition (EMT) process
contribute to the poor survival rate of patients with osteosarcoma (OS). Long noncoding …

Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore,
identification of novel targets remains extremely important to prevent metastasis and treat …

Highlights•Osteosarcoma is a disease resulting from osteogenic differentiation
defects.•Differentiation therapy for osteosarcoma has received extensive attention.•Various …

MicroRNAs (miRNAs) as small non-coding RNAs act as either tumor suppressors or
oncogenes in human cancers, of which miR-149-5p (miR-149) is involved in tumor growth …