Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Mitochondria are cellular energy powerhouses that play important roles in maintaining cell
survival, cell death and cellular metabolic homeostasis. Timely removal of damaged …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

Mitochondria are highly dynamic organelles and their proper function is crucial for the
maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two …

Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology
representing intense therapeutic challenges. It is well known that deregulation of …

The accumulation of deleterious mitochondrial DNA (∆ mtDNA) causes inherited
mitochondrial diseases and ageing-associated decline in mitochondrial functions such as …

Mitochondria are compartmentalized organelles essential for numerous cellular functions
including ATP generation, iron-sulfur cluster biogenesis, nucleotide and amino acid …

Cells respond to defects in mitochondrial function by activating signaling pathways that
restore homeostasis. The mitochondrial peptide exporter HAF-1 and the bZip transcription …