Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Study Design. Review and reinterpretation of existing literature. Objective. To suggest how
intervertebral disc degeneration might be distinguished from the physiologic processes of …

Study Design. A review of the literature on disc nutrition. Objectives. To summarize the
information on disc nutrition in relation to disc degeneration. Summary of the Background …

Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

We review the evidence that there are two types of disc degeneration.'E ndplate‐driven'disc
degeneration involves endplate defects and inwards collapse of the annulus, has a high …

Since the publication of the 2nd edition of White and Panjabi׳ s textbook, Clinical
Biomechanics of the Spine in 1990, there has been considerable research on the …

Study Design. We evaluated the degenerative changes to rat tail vertebral discs induced by
percutaneous needle puncture, and we compared 2 puncture styles for the depth of needle …

Loading is important to maintain the balance of matrix turnover in the intervertebral disc
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …

The metabolic environment of disc cells is governed by the avascular nature of the tissue.
Because cellular energy metabolism occurs mainly through glycolysis, the disc cells require …