Toxoplasma gondii is a ubiquitous parasitic protist found in a wide variety of hosts, including
a large proportion of the human population. Beyond an acute phase which is generally self …

Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

Secreted virulence factors of Toxoplasma to survive in immune-competent hosts have been
extensively explored by classical genetics and in vivo CRISPR screen methods, whereas …

The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the
ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways …

Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle
in Plasmodium falciparum malaria parasites and is required for prenylation-dependent …

Like many other apicomplexan parasites, Toxoplasma gondii contains a plastid harboring
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …

Iron is essential to cells as a cofactor in enzymes of respiration and replication, however
without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast …

Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however,
resistance threatens to undermine global control efforts. To broadly explore artemisinin …