Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …

Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …

The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …

The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …

The development of in vitro seed amplification assays (SAA) detecting misfolded alpha-
synuclein (αSyn) in cerebrospinal fluid (CSF) and other tissues has provided a pathology …

CWD is an emergent prion disease that now affects cervid species on three continents. CWD
is efficiently spread in wild and captive populations, likely through both direct animal contact …

The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event
in the pathogenesis of different neurodegenerative disorders grouped under the term of …

Chronic wasting disease (CWD) is an emergent, rapidly spreading prion disease of cervids.
Shedding of infectious prions in saliva and urine is thought to be an important factor in CWD …

Chronic wasting disease (CWD) is a fatal neurodegenerative disease of deer, elk, moose,
and reindeer (cervids) caused by misfolded prion proteins. The disease has been reported …

Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion
disease of cervids, would be aided by the availability of additional diagnostic tools. RT-QuIC …