Chronic wasting disease in Europe: new strains on the horizon
MA Tranulis, D Gavier-Widén, J Våge… - Acta Veterinaria …, 2021 - Springer
Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …
humans and a few other mammalian species. The diseases are experimentally …
The ecology of chronic wasting disease in wildlife
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …
diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic …
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
BR Groveman, CD Orrù, AG Hughson… - Acta neuropathologica …, 2018 - Springer
The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …
Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology …
The development of in vitro seed amplification assays (SAA) detecting misfolded alpha-
synuclein (αSyn) in cerebrospinal fluid (CSF) and other tissues has provided a pathology …
synuclein (αSyn) in cerebrospinal fluid (CSF) and other tissues has provided a pathology …
Shedding and stability of CWD prion seeding activity in cervid feces
JM Tennant, M Li, DM Henderson, ML Tyer… - PloS one, 2020 - journals.plos.org
CWD is an emergent prion disease that now affects cervid species on three continents. CWD
is efficiently spread in wild and captive populations, likely through both direct animal contact …
is efficiently spread in wild and captive populations, likely through both direct animal contact …
Are we ready for detecting α-synuclein prone to aggregation in patients? The case of “protein-misfolding cyclic amplification” and “real-time quaking-induced …
The accumulation and deposition of α-synuclein aggregates in brain tissue is the main event
in the pathogenesis of different neurodegenerative disorders grouped under the term of …
in the pathogenesis of different neurodegenerative disorders grouped under the term of …
Longitudinal detection of prion shedding in saliva and urine by chronic wasting disease-infected deer by real-time quaking-induced conversion
DM Henderson, ND Denkers, CE Hoover… - Journal of …, 2015 - Am Soc Microbiol
Chronic wasting disease (CWD) is an emergent, rapidly spreading prion disease of cervids.
Shedding of infectious prions in saliva and urine is thought to be an important factor in CWD …
Shedding of infectious prions in saliva and urine is thought to be an important factor in CWD …
Mineral licks as environmental reservoirs of chronic wasting disease prions
IH Plummer, CJ Johnson, AR Chesney, JA Pedersen… - PloS one, 2018 - journals.plos.org
Chronic wasting disease (CWD) is a fatal neurodegenerative disease of deer, elk, moose,
and reindeer (cervids) caused by misfolded prion proteins. The disease has been reported …
and reindeer (cervids) caused by misfolded prion proteins. The disease has been reported …
Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear
NC Ferreira, JM Charco, J Plagenz, CD Orru… - Scientific reports, 2021 - nature.com
Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion
disease of cervids, would be aided by the availability of additional diagnostic tools. RT-QuIC …
disease of cervids, would be aided by the availability of additional diagnostic tools. RT-QuIC …