[HTML][HTML] Neuroprotective approach of anti-cancer microtubule stabilizers against tauopathy associated dementia: Current status of clinical and preclinical findings
P Duggal, S Mehan - Journal of Alzheimer's disease reports, 2019 - content.iospress.com
Neuronal microtubule (MT) tau protein provides cytoskeleton to neuronal cells and plays a
vital role including maintenance of cell shape, intracellular transport, and cell division. Tau …
vital role including maintenance of cell shape, intracellular transport, and cell division. Tau …
[HTML][HTML] Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism
T Spisák, V Román, E Papp, R Kedves, K Sághy… - Scientific Reports, 2019 - nature.com
While cerebellar alterations may play a crucial role in the development of core autism
spectrum disorder (ASD) symptoms, their pathophysiology on the function of …
spectrum disorder (ASD) symptoms, their pathophysiology on the function of …
[HTML][HTML] Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis
Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce
neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the …
neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the …
[HTML][HTML] Acupuncture can regulate the peripheral immune cell spectrum and inflammatory environment of the vascular dementia rat, and improve the cognitive …
P Pan, Z Ma, Z Zhang, Z Ling, Y Wang, Q Liu… - Frontiers in Aging …, 2021 - frontiersin.org
Objective The aim of this study is to analyze the effects of acupuncture on peripheral
immune function, inflammation, and cognitive impairment in vascular dementia (VD) rats …
immune function, inflammation, and cognitive impairment in vascular dementia (VD) rats …
[HTML][HTML] Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats
During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases,
leading to cognitive impairments and neurodegenerative disorders, such as vascular …
leading to cognitive impairments and neurodegenerative disorders, such as vascular …
[HTML][HTML] Measurement of cortical atrophy and its correlation to memory impairment in patients with asymptomatic carotid artery stenosis based on VBM-DARTEL
P Wang, H Cai, R Luo, Z Zhang, D Zhang… - Frontiers in Aging …, 2021 - frontiersin.org
Objective Severe carotid artery stenosis (CAS) can lead to atrophy of gray matter (GM) and
memory impairment; however, the underlying mechanism is unknown. Thus, we aimed to …
memory impairment; however, the underlying mechanism is unknown. Thus, we aimed to …
Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis
S Maimaitiaili, C Tang, C Liu, X Lv, Z Chen… - Frontiers in Aging …, 2024 - frontiersin.org
Background Patients with carotid atherosclerotic stenosis (CAS) often have varying degrees
of cognitive decline. However, there is little evidence regarding how brain morphological …
of cognitive decline. However, there is little evidence regarding how brain morphological …
Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors
B Zhang, L Wu, Q Zhu, Y Dong, L Sun - Neuroscience Letters, 2021 - Elsevier
Cancer-induced bone pain (CIBP), which is associated with poor quality of life, is most
commonly treated using opioids. However, long-term use of morphine for analgesia induces …
commonly treated using opioids. However, long-term use of morphine for analgesia induces …
Ameliorative effect of phosphodiesterase-5 inhibitor in rat model of vascular dementia
Introduction: Cerebral hypoperfusion has been considered as major risk factor for Vascular
Dementia (VaD). The present study shows the potential of Tadalafil, a phosphodiesterase-5 …
Dementia (VaD). The present study shows the potential of Tadalafil, a phosphodiesterase-5 …
[HTML][HTML] Deciphering the scopolamine challenge rat model by preclinical functional MRI
G Somogyi, D Hlatky, T Spisák, Z Spisák, G Nyitrai… - Scientific Reports, 2021 - nature.com
During preclinical drug testing, the systemic administration of scopolamine (SCO), a
cholinergic antagonist, is widely used. However, it suffers important limitations, like non …
cholinergic antagonist, is widely used. However, it suffers important limitations, like non …