[HTML][HTML] Neuroprotective approach of anti-cancer microtubule stabilizers against tauopathy associated dementia: Current status of clinical and preclinical findings

P Duggal, S Mehan - Journal of Alzheimer's disease reports, 2019 - content.iospress.com
Neuronal microtubule (MT) tau protein provides cytoskeleton to neuronal cells and plays a
vital role including maintenance of cell shape, intracellular transport, and cell division. Tau …

[HTML][HTML] Purkinje cell number-correlated cerebrocerebellar circuit anomaly in the valproate model of autism

T Spisák, V Román, E Papp, R Kedves, K Sághy… - Scientific Reports, 2019 - nature.com
While cerebellar alterations may play a crucial role in the development of core autism
spectrum disorder (ASD) symptoms, their pathophysiology on the function of …

[HTML][HTML] Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis

V Tukacs, D Mittli, É Hunyadi-Gulyás, D Hlatky… - Molecular …, 2023 - Springer
Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce
neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the …

[HTML][HTML] Acupuncture can regulate the peripheral immune cell spectrum and inflammatory environment of the vascular dementia rat, and improve the cognitive …

P Pan, Z Ma, Z Zhang, Z Ling, Y Wang, Q Liu… - Frontiers in Aging …, 2021 - frontiersin.org
Objective The aim of this study is to analyze the effects of acupuncture on peripheral
immune function, inflammation, and cognitive impairment in vascular dementia (VD) rats …

[HTML][HTML] Chronic stepwise cerebral hypoperfusion differentially induces synaptic proteome changes in the frontal cortex, occipital cortex, and hippocampus in rats

V Tukacs, D Mittli, BA Györffy, É Hunyady-Gulyás… - Scientific reports, 2020 - nature.com
During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases,
leading to cognitive impairments and neurodegenerative disorders, such as vascular …

[HTML][HTML] Measurement of cortical atrophy and its correlation to memory impairment in patients with asymptomatic carotid artery stenosis based on VBM-DARTEL

P Wang, H Cai, R Luo, Z Zhang, D Zhang… - Frontiers in Aging …, 2021 - frontiersin.org
Objective Severe carotid artery stenosis (CAS) can lead to atrophy of gray matter (GM) and
memory impairment; however, the underlying mechanism is unknown. Thus, we aimed to …

Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis

S Maimaitiaili, C Tang, C Liu, X Lv, Z Chen… - Frontiers in Aging …, 2024 - frontiersin.org
Background Patients with carotid atherosclerotic stenosis (CAS) often have varying degrees
of cognitive decline. However, there is little evidence regarding how brain morphological …

Donepezil attenuates the development of morphine tolerance in rats with cancer-induced bone pain: The role of cortical N-methyl-D-aspartate receptors

B Zhang, L Wu, Q Zhu, Y Dong, L Sun - Neuroscience Letters, 2021 - Elsevier
Cancer-induced bone pain (CIBP), which is associated with poor quality of life, is most
commonly treated using opioids. However, long-term use of morphine for analgesia induces …

Ameliorative effect of phosphodiesterase-5 inhibitor in rat model of vascular dementia

P Bhatia, N Singh - Current Neurovascular Research, 2019 - ingentaconnect.com
Introduction: Cerebral hypoperfusion has been considered as major risk factor for Vascular
Dementia (VaD). The present study shows the potential of Tadalafil, a phosphodiesterase-5 …

[HTML][HTML] Deciphering the scopolamine challenge rat model by preclinical functional MRI

G Somogyi, D Hlatky, T Spisák, Z Spisák, G Nyitrai… - Scientific Reports, 2021 - nature.com
During preclinical drug testing, the systemic administration of scopolamine (SCO), a
cholinergic antagonist, is widely used. However, it suffers important limitations, like non …