Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

The rapid emergence of metabolomics has enabled system-wide measurements of
metabolites in various organisms. However, advances in the mechanistic understanding of …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

Direct in vivo investigation of mammalian metabolism is complicated by the distinct
metabolic functions of different tissues. We present a computational method that successfully …

Predictive microbiology in foods is a research area within food microbiology intended to
provide mathematical models to predict microbial behavior in food environments. Although …

Metabolic pathway analysis is becoming increasingly important for assessing inherent
network properties in (reconstructed) biochemical reaction networks. Of the two most …

Metabolic pathways are a central paradigm in biology. Historically, they have been defined
on the basis of their step-by-step discovery. However, the genome-scale metabolic networks …

Background Metabolic pathway analysis has been recognized as a central approach to the
structural analysis of metabolic networks. The concept of elementary (flux) modes provides a …

The constraint-based analysis of genome-scale metabolic and regulatory networks has
been successful in predicting phenotypes and useful for analyzing high-throughput data …

Motivation: The analysis of structure, pathways and flux distributions in metabolic networks
has become an important approach for understanding the functionality of metabolic systems …