The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Background: Paclitaxel (PTX) is a widely used anti-cancer drug for treating various types of
solid malignant tumors including breast, ovarian and lung cancers. However, PTX has a low …

One of the key problems that have hindered the development and approval of anticancer
nanoparticle drug delivery systems is the limited predictability of 2D cell culture and animal …

Albumin is the most abundant protein in blood, and is the most frequently identified protein
in the protein corona of nanoparticles (NPs). Thus, albumin plays an important role in …

Background The inherent poor druggability of numerous active pharmaceutical ingredients
(APIs) necessitate the modification of their physicochemical and biopharmaceutical …

Purpose To conjugate different degree of saturation of C18 fatty acids (stearic acid, oleic
acid, and linoleic acid) with the hydroxyl groups of leuprolide acetate (LEU acetate) and to …

In the present work Stealth liposomes were conjugated with transferrin (Tf) for sirolimus
(SRM) active targeting and the treatment of breast cancer. The developed Tf-Stealth …

Solubilizing adjuvants are commonly used to dissolve insoluble drugs by simply adding in a
formulation. In this study, gelatin and oleic acid sodium salt (OAS), a generally recognized …

Nanoparticle-protein interactions under conditions mimicking physiology determine how
nanoparticles (NPs) will behave inside blood vessels and, therefore, the overall outcome of …

This study aimed to design the ideal nanonizing vehicle for poorly water-soluble model
curcumin (CCM) using fattigation-platform nanotechnology, and to investigate the effects of …