Blood plasma self-separation technologies during the self-driven flow in microfluidic platforms

Y Wang, BB Nunna, N Talukder, EE Etienne, ES Lee - Bioengineering, 2021 - mdpi.com
Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical
analysis due to it contains various biomarkers. The majority of the blood plasma separation …

A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks

S Ebrahimi, P Bagchi - Scientific reports, 2022 - nature.com
Capillary blood vessels, the smallest vessels in the body, form an intricate network with
constantly bifurcating, merging and winding vessels. Red blood cells (RBCs) must navigate …

A few upstream bifurcations drive the spatial distribution of red blood cells in model microfluidic networks

A Merlo, M Berg, P Duru, F Risso, Y Davit, S Lorthois - Soft Matter, 2022 - pubs.rsc.org
The physics of blood flow in small vessel networks is dominated by the interactions between
Red Blood Cells (RBCs), plasma and blood vessel walls. The resulting couplings between …

Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations

Q Zhou, J Fidalgo, MO Bernabeu, MSN Oliveira… - Soft Matter, 2021 - pubs.rsc.org
Blood is a vital soft matter, and its normal circulation in the human body relies on the
distribution of red blood cells (RBCs) at successive bifurcations. Understanding how RBCs …

Red blood cell lingering modulates hematocrit distribution in the microcirculation

Y Rashidi, G Simionato, Q Zhou, T John, A Kihm… - Biophysical …, 2023 - cell.com
The distribution of red blood cells (RBCs) in the microcirculation determines the oxygen
delivery and solute transport to tissues. This process relies on the partitioning of RBCs at …

Anomalous diffusion of deformable particles in a honeycomb network

Z Shen, F Plouraboué, JS Lintuvuori, H Zhang… - Physical Review Letters, 2023 - APS
Transport of deformable particles in a honeycomb network is studied numerically. It is shown
that the particle deformability has a strong impact on their distribution in the network. For …

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

Q Zhou, T Perovic, I Fechner… - Journal of the …, 2021 - royalsocietypublishing.org
Sprouting angiogenesis is an essential vascularization mechanism consisting of sprouting
and remodelling. The remodelling phase is driven by rearrangements of endothelial cells …

Application of machine learning in predicting blood flow and red cell distribution in capillary vessel networks

S Ebrahimi, P Bagchi - Journal of the Royal Society …, 2022 - royalsocietypublishing.org
Capillary blood vessels in the body partake in the exchange of gas and nutrients with
tissues. They are interconnected via multiple vascular junctions forming the microvascular …

[HTML][HTML] Hierarchical regularization of solution ambiguity in underdetermined inverse and optimization problems

R Epp, F Schmid, P Jenny - Journal of Computational Physics: X, 2022 - Elsevier
Estimating modeling parameters based on a prescribed optimization target requires to solve
an inverse problem, which is commonly ill-posed. Consequently, either infinitely many or no …

Local vs. global blood flow modulation in artificial microvascular networks: effects on red blood cell distribution and partitioning

A Mantegazza, M Ungari, F Clavica, D Obrist - Frontiers in physiology, 2020 - frontiersin.org
Our understanding of cerebral blood flow (CBF) regulation during functional activation is still
limited. Alongside with the accepted role of smooth muscle cells in controlling the arteriolar …