The number of membrane protein structures in the Protein Data Bank is becoming significant
and growing. Here, the transmembrane domain structures of the helical membrane proteins …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The role of cholesterol in eukaryotic membrane protein function has been attributed primarily
to an influence on membrane fluidity and curvature. We present the 2.8 Å resolution crystal …

Systematic efforts to understand membrane protein stability under a variety of different
solution conditions are not widely available for membrane proteins, mainly due to technical …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Helical integral membrane proteins share several structural determinants that are widely
conserved across their universe. The discovery of common motifs has furthered our …

One of the great challenges for molecular biologists is to learn how a protein sequence
defines its three-dimensional structure. For many years, the problem was even more difficult …

We describe the adaptation of the Rosetta de novo structure prediction method for prediction
of helical transmembrane protein structures. The membrane environment is modeled by …

Background Members of major intrinsic proteins (MIPs) include water-conducting
aquaporins and glycerol-transporting aquaglyceroporins. MIPs play important role in plant …

Biologic membranes are not simply inert physical barriers, but complex and dynamic
environments that affect membrane protein structure and function. Residing within these …