Enzymes, In Vivo Biocatalysis, and Metabolic Engineering for Enabling a Circular Economy and Sustainability
Since the industrial revolution, the rapid growth and development of global industries have
depended largely upon the utilization of coal-derived chemicals, and more recently, the …
depended largely upon the utilization of coal-derived chemicals, and more recently, the …
Oxygen activation and radical transformations in heme proteins and metalloporphyrins
As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …
Recent structural insights into cytochrome P450 function
FP Guengerich, MR Waterman, M Egli - Trends in pharmacological …, 2016 - cell.com
Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …
Formation and cleavage of C–C bonds by enzymatic oxidation–reduction reactions
FP Guengerich, FK Yoshimoto - Chemical Reviews, 2018 - ACS Publications
Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
[HTML][HTML] Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology
Highlights•Cytochrome P450 enzymes catalyse oxygen insertion into a wide range of
substrates.•Mutagenesis of P450s frequently allows novel substrate recognition.•P450s …
substrates.•Mutagenesis of P450s frequently allows novel substrate recognition.•P450s …
Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism
A Greule, JE Stok, JJ De Voss, MJ Cryle - Natural product reports, 2018 - pubs.rsc.org
Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …
containing monooxygenases that perform diverse catalytic roles in many species, including …
Structure and function of the cytochrome P450 peroxygenase enzymes
The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily,
members of which catalyze the oxidative transformation of a wide range of organic …
members of which catalyze the oxidative transformation of a wide range of organic …
Inspiration from Nature: influence of engineered ligand scaffolds and auxiliary factors on the reactivity of biomimetic oxidants
Enzymes are highly efficient catalysts in Nature that often react with high stereo-, chemo-,
and regioselectivity. Usually, enzymes achieve this selectivity through substrate binding and …
and regioselectivity. Usually, enzymes achieve this selectivity through substrate binding and …
Hemoprotein catalyzed oxygenations: P450s, UPOs, and progress toward scalable reactions
G Grogan - JACS Au, 2021 - ACS Publications
The selective oxygenation of nonactivated carbon atoms is an ongoing synthetic challenge,
and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their …
and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their …
Light-driven biocatalytic oxidation
Enzymes are the catalyst of choice for highly selective reactions, offering nature-inspired
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases …
approaches for sustainable chemical synthesis. Oxidative enzymes (eg, monooxygenases …