The P2X7 receptor: a main player in inflammation
Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
The P2X7 receptor: central hub of brain diseases
R Andrejew, Á Oliveira-Giacomelli… - Frontiers in Molecular …, 2020 - frontiersin.org
The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
Structural basis for subtype-specific inhibition of the P2X7 receptor
A Karasawa, T Kawate - elife, 2016 - elifesciences.org
The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine
triphosphate (ATP). Chronic activation of P2X7 underlies many health problems such as …
triphosphate (ATP). Chronic activation of P2X7 underlies many health problems such as …
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
K Recourt, P de Boer, P van der Ark, H Benes… - Translational …, 2023 - nature.com
JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …
P2X7 receptor: an emerging target in central nervous system diseases
B Sperlágh, P Illes - Trends in pharmacological sciences, 2014 - cell.com
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …
potential drug target because of its widespread involvement in inflammatory diseases as a …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Medicinal chemistry of adenosine, P2Y and P2X receptors
KA Jacobson, CE Müller - Neuropharmacology, 2016 - Elsevier
Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2X7 in cancer: from molecular mechanisms to therapeutics
R Lara, E Adinolfi, CA Harwood, M Philpott… - Frontiers in …, 2020 - frontiersin.org
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
The P2X7 receptor
R Sluyter - Protein Reviews: Volume 19, 2017 - Springer
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …
triphosphate. The receptor is present on an increasing number of different cells types …