Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …

We compare and contrast the genetic architecture of quantitative phenotypes in two
genetically well-characterized model organisms, the laboratory mouse, Mus musculus, and …

Quantitative trait locus (QTL) analysis is a statistical method that links two types of
information—phenotypic data (trait measurements) and genotypic data (usually molecular …

Understanding neurotoxic mechanisms is a challenge of deciphering which genes and gene
products in the developing or mature nervous system are targeted for disruption by …

Aging or senescence is an age-dependent decline in physiological function,
demographically manifest as decreased survival and fecundity with increasing age. Since …

Latitudinal clines are widespread in Drosophila melanogaster, and many have been
interpreted as adaptive responses to climatic variation. However, the selective mechanisms …

Understanding the genetic basis of variation in life span is a major challenge that is difficult
to address in human populations. Evolutionary theory predicts that alleles affecting natural …

Life history traits are critical components of fitness and frequently reflect adaptive responses
to environmental pressures. However, few genes that contribute to natural life history …

It is generally accepted that the permanent arrest of cell division known as cellular
senescence contributes to aging by an antagonistic pleiotropy mechanism: cellular …

Quantitative genetics is at or is fast approaching its centennial. In this perspective I consider
five current issues pertinent to the application of quantitative genetics to evolutionary theory …