Hydrogenases (H2ases) catalyze the reversible oxidation of molecular hydrogen and play a
central role in microbial energy metabolism. Most of these enzymes are found in Archaea …

Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes
have alternative splice forms, suggesting that alternative splicing is one of the most …

The construction of high capacity data sharing networks to support increasing government
and commercial data exchange has highlighted a key roadblock: the content of existing …

Background Treatment with the α-glucosidase inhibitor acarbose increases median lifespan
by approximately 20% in male mice and 5% in females. This longevity extension differs from …

Abstract The Protein Data Bank (PDB; http://www. rcsb. org/pdb/) is the single worldwide
archive of structural data of biological macromolecules. This paper describes the goals of …

ABSTRACT The Ribosomal Database Project (RDP) Classifier, a naïve Bayesian
classifier, can rapidly and accurately classify bacterial 16S rRNA sequences into the new …

The distributed nature of biological knowledge poses a major challenge to the interpretation
of genome-scale datasets, including those derived from microarray and proteomic studies …

Background Comparative analysis of RNA sequences is the basis for the detailed and
accurate predictions of RNA structure and the determination of phylogenetic relationships for …

IntAct provides an open source database and toolkit for the storage, presentation and
analysis of protein interactions. The web interface provides both textual and graphical …

Abstract The Ribosomal Database Project (RDP-II) provides the research community with
aligned and annotated rRNA gene sequences, along with analysis services and a …