Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Background: Psoriasis is a common, chronic inflammatory skin disorder, which can
significantly impact quality of life. Despite major breakthroughs in our understanding of the …

Chemokines are signaling peptides which regulate cell trafficking and provide control of the
tissue-specific cell homing. In the skin, chemokines are secreted both by the resident cells …

Background Psoriasis is a chronic inflammatory disease associated with an increased
cardiovascular risk. Metabolic syndrome is a significant predictor of cardiovascular events …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities
associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its …

Targeted biologic therapies have revolutionised treatment of immune-mediated
inflammatory diseases (IMIDs) due to their efficacy, speed of onset and tolerability. The …

The occurrence of arthritis in patients with psoriasis has been recognized since the 19th
century. However, psoriatic arthritis (PsA) was identified as a distinct entity primarily as a …

Psoriasis is a chronic inflammatory skin disease that is associated with an increased
cardiovascular risk profile. The systemic inflammation present in psoriasis, various systemic …

Background Guttate psoriasis is common and affects 0.5–2% of individuals in the paediatric
age group. This review aims to familiarize physicians with the clinical manifestations …

Fumaric acid esters (FAEs) such as dimethylfumarate (DMF) are used for the treatment of
adults with moderate‐to‐severe psoriasis. The mode of action of FAEs is complex. Here, we …