Lysosomal TRPML1 triggers global Ca2+ signals and nitric oxide release in human cerebrovascular endothelial cells

V Brunetti, R Berra-Romani, F Conca, T Soda… - Frontiers in …, 2024 - frontiersin.org
Lysosomal Ca2+ signaling is emerging as a crucial regulator of endothelial Ca2+ dynamics.
Ca2+ release from the acidic vesicles in response to extracellular stimulation is usually …

Targeting the Ca2+ signaling toolkit as an alternative strategy to mitigate SARS-CoV-2-induced cardiovascular adverse events

S Scorza, V Brunetti, G Scarpellino, M Certini… - Vascular …, 2024 - Elsevier
Ca 2+ signaling events are essential for maintaining cardiovascular health, regulating
critical functions in both endothelial and cardiac cells. SARS-CoV-2 infection impinges this …