Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase
(ERK) pathways play important roles in the tumorigenesis of many different types of cancer …

The Wnt signaling pathway is a highly conserved regulator of metazoan development and
stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies …

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and
maintenance of cancer stem cells. However, how other oncogenic pathways converge on …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

Although the guanosine triphosphate/guanosine diphosphate loading switch is a major
regulatory mechanism that controls the activity of the guanosine triphosphatase Ras, we …

Oncogenic mutations in the K-ras gene occur in≈ 50% of human colorectal cancers.
However, the precise role that K-ras oncogenes play in tumor formation is still unclear. To …

Epithelial-mesenchymal transition (EMT) is a key event in the generation of invasive tumor
cells. A hallmark of EMT is the repression of E-cadherin expression, which is regulated by …

Both the Wnt/β-catenin and Ras pathways are aberrantly activated in most human colorectal
cancers (CRCs) and interact cooperatively in tumor promotion. Inhibition of these signaling …

A vast effort has been invested in the identification of driver mutations of cancer. However,
recent studies and observations call into question whether the activating mutations or the …

Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular
immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at …