With the explosion of neuroimaging, differences between male and female brains have been
exhaustively analyzed. Here we synthesize three decades of human MRI and postmortem …

The use of evidence from clinical trials to support decisions for individual patients is a form of
“reference class forecasting”: implicit predictions for an individual are made on the basis of …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …

As part of an initiative to improve rigor and reproducibility in biomedical research, the US
National Institutes of Health now requires the consideration of sex as a biological variable in …

Importance Dietary modification remains key to successful weight loss. Yet, no one dietary
strategy is consistently superior to others for the general population. Previous research …

Objective To quantify the risk of overall and type specific cardiovascular and
cerebrovascular diseases as well as venous thromboembolism in women with a history of …

A sex-and gender-informed perspective increases rigor, promotes discovery, and expands
the relevance of biomedical research. In the current era of accountability to present data for …

Importance Analyses of female representation in clinical studies have been limited in scope
and scale. Objective To perform a large-scale analysis of global enrollment sex bias in …

The PATH (Predictive Approaches to Treatment effect Heterogeneity) Statement was
developed to promote the conduct of, and provide guidance for, predictive analyses of …

To enhance inclusivity and rigor, many funding agencies and journals now mandate the
inclusion of females as well as males in biomedical studies. These mandates have …