Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

Significance: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is
encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to …

Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt),
and is associated with a variety of cellular dysfunctions including excessive mitochondrial …

The tumor suppressor protein p53 is a redox-active transcription factor that organizes and
directs cellular responses in the face of a variety of stresses that lead to genomic instability …

Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

Members of the class O of forkhead box transcription factors (FoxO) have important roles in
metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of …