PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Y Su, B Zhang, R Sun, W Liu, Q Zhu, X Zhang… - Drug …, 2021 - Taylor & Francis
Biodegradable microspheres have been widely used in the field of medicine due to their
ability to deliver drug molecules of various properties through multiple pathways and their …

Phenomenology of the initial burst release of drugs from PLGA microparticles

J Yoo, YY Won - ACS Biomaterials Science & Engineering, 2020 - ACS Publications
Poly (lactic-co-glycolic acid)(PLGA) is the most prevalent polymer drug delivery vehicle in
use today. There are about 20 commercialized drug products in which PLGA is used as an …

Properties of poly (lactic-co-glycolic acid) and progress of poly (lactic-co-glycolic acid)-based biodegradable materials in biomedical research

Y Lu, D Cheng, B Niu, X Wang, X Wu, A Wang - Pharmaceuticals, 2023 - mdpi.com
In recent years, biodegradable polymers have gained the attention of many researchers for
their promising applications, especially in drug delivery, due to their good biocompatibility …

[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

PLGA-based nanomedicine: history of advancement and development in clinical applications of multiple diseases

HO Alsaab, FD Alharbi, AS Alhibs, NB Alanazi… - Pharmaceutics, 2022 - mdpi.com
Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding

B Wan, Q Bao, D Burgess - Advanced drug delivery reviews, 2023 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microspheres are a sustained-release drug delivery
system with several successful commercial products used for the treatment of a variety of …

A review on novel methodologies for drug nanoparticle preparation: Microfluidic approach

P Shrimal, G Jadeja, S Patel - Chemical Engineering Research and Design, 2020 - Elsevier
The intrinsic limitations of conventional dosages have facilitated the emergence of novel
drug delivery methodologies. Drug nanonization and encapsulation in polymeric …

Cytotoxicity of targeted PLGA nanoparticles: A systematic review

HI Chiu, NA Samad, L Fang, V Lim - RSC advances, 2021 - pubs.rsc.org
Recent advances in nanotechnology have contributed tremendously to the development
and revolutionizing of drug delivery systems in the field of nanomedicine. In particular …

Challenges and Complications of Poly(lactic-co-glycolic acid)-Based Long-Acting Drug Product Development

YW Lim, WS Tan, KL Ho, AR Mariatulqabtiah… - Pharmaceutics, 2022 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the preferred polymeric inactive ingredients for
long-acting parenteral drug products that are constituted of complex formulations. Despite …