Target identification and intervention strategies against amebiasis

S Nagaraja, S Ankri - Drug Resistance Updates, 2019 - Elsevier
Entamoeba histolytica is the etiological agent of amebiasis, which is an endemic parasitic
disease in developing countries and is the cause of approximately 70,000 deaths annually …

Regulation of gene expression in protozoa parasites

C Gomez, M Esther Ramirez… - BioMed Research …, 2010 - Wiley Online Library
Infections with protozoa parasites are associated with high burdens of morbidity and
mortality across the developing world. Despite extensive efforts to control the transmission of …

[HTML][HTML] Advances in protozoan epigenetic targets and their inhibitors for the development of new potential drugs

C Gaona-López, LK Vazquez-Jimenez… - Pharmaceuticals, 2023 - mdpi.com
Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors
such as climate change, extreme poverty, migration, and a lack of life opportunities lead to …

[HTML][HTML] Screening and Structural Characterization of Heat Shock Response Elements (HSEs) in Entamoeba histolytica Promoters

D Dorantes-Palma, S Pérez-Mora… - International Journal of …, 2024 - mdpi.com
Entamoeba histolytica (E. histolytica) exhibits a remarkable capacity to respond to thermal
shock stress through a sophisticated genetic regulation mechanism. This process is carried …

Identification of an Entamoeba histolytica Serine-, Threonine-, and Isoleucine-Rich Protein with Roles in Adhesion and Cytotoxicity

RC MacFarlane, U Singh - Eukaryotic Cell, 2007 - Am Soc Microbiol
Entamoeba histolytica is a leading cause of parasitic death globally. However, the molecular
framework regulating pathogenesis is poorly understood. We have previously used …

[HTML][HTML] Glucose Starvation Boosts Entamoeba histolytica Virulence

A Tovy, R Hertz, R Siman-Tov, S Syan… - PLoS neglected …, 2011 - journals.plos.org
The unicellular parasite, Entamoeba histolytica, is exposed to numerous adverse conditions,
such as nutrient deprivation, during its life cycle stages in the human host. In the present …

Toll-Like Receptor 9-Dependent Macrophage Activation by Entamoeba histolytica DNA

CPA Ivory, M Prystajecky, C Jobin… - Infection and …, 2008 - Am Soc Microbiol
Activation of the innate immune system by bacterial DNA and DNA of other invertebrates
represents a pathogen recognition mechanism. In this study we investigated macrophage …

The Entamoeba histolytica Dnmt2 homolog (Ehmeth) confers resistance to nitrosative stress

R Hertz, A Tovy, M Kirschenbaum, M Geffen… - Eukaryotic …, 2014 - Am Soc Microbiol
Nitric oxide (NO) has antimicrobial properties against many pathogens due to its reactivity as
an S-nitrosylating agent. It inhibits many of the key enzymes that are involved in the …

[HTML][HTML] Biological function molecular pathways and druggability of DNMT2/TRDMT1

H Li, H Liu, D Zhu, C Dou, B Gang, M Zhang… - Pharmacological …, 2024 - Elsevier
methylcytosine (m 5 C) is among the most common epigenetic modification in DNA and RNA
molecules, and plays an important role in the animal development and disease …

[HTML][HTML] Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression

IKM Ali, GM Ehrenkaufer, JA Hackney, U Singh - BMC genomics, 2007 - Springer
Background In higher eukaryotes DNA methylation regulates important biological functions
including silencing of gene expression and protection from adverse effects of …