The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Survivors of childhood cancer experience substantial premature mortality; in the British
Childhood Cancer Survivor Study (BCCSS) cohort, by 50 years from diagnosis 30% of 5 …

Among the most pressing issues in the field of illness diagnostics is identifying and
diagnosing leukemia at its earliest stages, which requires accurate distinction of malignant …

Purpose To facilitate the initiation of observational studies on late effects of proton therapy in
pediatric patients, we report on current patterns of proton therapy use worldwide in patients …

Purpose Leaders in the oncology community are sounding a clarion call to promote “value”
in cancer care decisions. Value in cancer care considers the clinical effectiveness, along …

As modern radiotherapy, including intensity-modulated techniques, is associated with high
dose gradients to normal tissues and large low-to-moderate dose volumes, the assessment …

Proper understanding of the risk of radiation-induced late effects for patients receiving
external photon beam radiotherapy requires the determination of reliable dose–response …

Report 1 of a three-part review examines the conceptual formulation and relevance of the
problem, including weak penetration of specific methodologies for causation proving into …

Childhood cancer survivors are at increased risk for second primary leukemia (SPL), but
there is little consensus on the magnitude of some risk factors because of the small size of …

Background Survivors of childhood cancers are at risk of developing subsequent primary
leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We …