Computable early Caenorhabditis elegans embryo with a phase field model

X Kuang, G Guan, MK Wong, LY Chan… - PLOS Computational …, 2022 - journals.plos.org
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis,
consisting of both cell proliferation and cell migration. Despite the fact that much is known …

MorphoSim: an efficient and scalable phase-field framework for accurately simulating multicellular morphologies

X Kuang, G Guan, C Tang, L Zhang - npj Systems Biology and …, 2023 - nature.com
The phase field model can accurately simulate the evolution of microstructures with complex
morphologies, and it has been widely used for cell modeling in the last two decades …

[HTML][HTML] Delineating the mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational …

G Guan, Z Zhao, C Tang - Computational and Structural Biotechnology …, 2022 - Elsevier
The nematode (roundworm) Caenorhabditis elegans is one of the most popular animal
models for the study of developmental biology, as its invariant development and transparent …

Apical PAR protein caps orient the mitotic spindle in C. elegans early embryos

NJ Stolpner, NI Manzi, T Su, DJ Dickinson - Current Biology, 2023 - cell.com
During embryonic development, oriented cell divisions are important for patterned tissue
growth and cell fate specification. Cell division orientation is controlled in part by …

[HTML][HTML] Apical PAR-3 caps orient the mitotic spindle in C. elegans early embryos

NJ Stolpner, NI Manzi, T Su, DJ Dickinson - BioRxiv, 2023 - ncbi.nlm.nih.gov
During embryonic development, oriented cell divisions are important for patterned tissue
growth and cell fate specification. Cell division orientation is controlled in part by …

EmbSAM: Cell boundary localization and Segment Anything Model for fast images of developing embryos

C Zhao, Z Li, P Zhang, Y Chen, P Ye, MK Wong… - bioRxiv, 2024 - biorxiv.org
Cellular shape dynamics are critical for understanding cell fate determination and
organogenesis during development. However, fluorescence live-cell images of cell …

A Maternal-Effect Toxin Affects Epithelial Differentiation and Tissue Mechanics in Caenorhabditis elegans

C Lehmann, C Pohl - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Selfish genetic elements that act as post-segregation distorters cause lethality in non-carrier
individuals after fertilization. Two post-segregation distorters have been previously identified …

Untersuchung des mikrovillären Bürstensaums im C. elegans Darmepithel mittels Puls-RNAi

S Adler - 2024 - kups.ub.uni-koeln.de
Enterozyten, die den Metazoen-Darm auskleiden, besitzen an ihrer apikalen Oberfläche
Aktin-basierte Membranausstülpungen, so genannte Mikrovilli, um durch diese …

The crosstalk between polarity proteins and cell cycle machinery in the early C. elegans embryos

NI Manzi - 2024 - repositories.lib.utexas.edu
Coordination of cell division and cell polarity is a critical cellular phenomenon that governs
proper development and morphogenesis. Cell polarity is particularly important during …

Computable Early C. elegans Embryo with a Data-driven Phase Field Model

X Kuang, G Guan, MK Wong, LY Chan, Z Zhao, C Tang… - bioRxiv, 2020 - biorxiv.org
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis,
consisting of both cell proliferation and cell migration. Despite the fact that much is known …