Planarians have a long history in the fields of developmental and regenerative biology.
These animals have also sparked interest in neuroscience due to their neuroanatomy …

More than 100 years ago, early workers realized that planarians offer an excellent system for
regeneration studies. Another unique aspect of planarians is that they occupy an interesting …

The planarian Dugesia japonica can regenerate a complete individual from a head, trunk or
tail fragment via activation of somatic pluripotent stem cells,. About a century ago, Thomas …

Despite long-standing interest, the molecular mechanisms underlying the establishment of
anterior–posterior (AP) polarity remain among the unsolved mysteries in metazoans. In the …

Introduction Planarians belong to an evolutionarily early group of organisms that possess a
central nervous system including a well-organized brain with a simple architecture but many …

Recent studies of the freshwater planarian Dugesia japonica have revealed fundamental
mechanisms and unique aspects of neuroscience and neuroregeneration. Here, we …

To achieve an integrated understanding of the stem cell system of planarians at both the
cellular and molecular levels, we developed a new method by combining “fluorescent …

Differentiation of pluripotent stem cells (PSCs) requires transposon silencing throughout the
process. PIWIs, best known as key factors in germline transposon silencing, are also known …

Planarians are free-living aquatic flatworms that possess a well-documented photophobic
response to light. With a true central nervous system and simple cerebral eyes (ocelli) …

For most organisms, sensitive recognition of even slight changes in environmental
temperature is essential for adjusting their behavioral strategies to ensure homeostasis and …