For many years, linkage analysis was the primary tool used for the genetic mapping of
Mendelian and complex traits with familial aggregation. Linkage analysis was largely …

Genome-wide association (GWA) studies are an effective approach for identifying genetic
variants associated with disease risk. GWA studies can be confounded by population …

The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Despite the yield of recent genome-wide association (GWA) studies, the identified variants
explain only a small proportion of the heritability of most complex diseases. This …

В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …

Mendelian and complex genetic trait diseases continue to burden and affect society both
socially and economically. The lack of effective tests has hampered diagnosis thus, the …

Objective To investigate whether filaggrin gene defects, present in up to one in 10 western
Europeans and North Americans, increase the risk of developing allergic sensitisation and …

Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …

Linkage disequilibrium (LD) mapping in plants detects and locates quantitative trait loci
(QTL) by the strength of the correlation between a trait and a marker. It offers greater …

Recent advances in plant genomics and molecular biology have revolutionized our
understanding of plant genetics, providing new opportunities for more efficient and …