Epilepsy is a chronic neurological disease that is characterized by spontaneous and
recurrent seizures. Regulated cell death is a controlled process and has been shown to be …

Valproic acid or valproate (VPA) is an anticonvulsive drug used for treatments of epilepsy,
bipolar disorder, and migraine headaches. VPA is also an epigenetic modulator, inhibiting …

The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism,
which is implicated in both the therapeutic mechanism of action of the drug as well as drug …

Fungi are talented organisms able to produce several natural products with a wide range of
structural and pharmacological activities. The conventional fungal cultivation used in …

Current antifungal drugs suffer from limitations including toxicity, the emergence of
resistance and decreased efficacy at low pH that are typical of human vaginal surfaces …

The evolutionarily-conserved sirtuin family of histone deacetylases regulates a multitude of
DNA-associated processes. A recent genome-wide screen conducted in the yeast …

Highlights•The Cu (II) complexes have higher cytotoxicity than sodium valproate.•Cu (II)
complexes and sodium valproate induced mutations in S. cerevisiae.•BER, NER or TLS …

Abstract Background/Aim: Valproic acid (VPA), is an antiepileptic drug and it has been
known for a long time that exposure to VPA in the fetal period causes many behavioral …

Before new chemicals can be put on the market, they must be evaluated for toxicological
safety. Evaluating the safety of new chemicals, for either medical, cosmetic or environmental …

Valproic acid or valproate (VPA) is a drug for the treatment of epilepsy, bipolar disorder,
migraine headaches and neuropathic pain. Unfortunately, VPA has many side effects. In this …