Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo - Pharmacological reviews, 2021 - ASPET
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Fluorescence nanoscopy in cell biology
Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
internal nanoscale structure and dynamics of cells and tissues with molecular detection …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Super-resolution structured illumination microscopy
R Heintzmann, T Huser - Chemical reviews, 2017 - ACS Publications
Super-resolved structured illumination microscopy (SR-SIM) is among the most rapidly
growing fluorescence microscopy techniques that can surpass the optical diffraction limit …
growing fluorescence microscopy techniques that can surpass the optical diffraction limit …
[HTML][HTML] Optical mapping of cAMP signaling at the nanometer scale
A Bock, P Annibale, C Konrad, A Hannawacker… - Cell, 2020 - cell.com
Cells relay a plethora of extracellular signals to specific cellular responses by using only a
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …
Cell-based biosensors: Recent trends, challenges and future perspectives
N Gupta, V Renugopalakrishnan, D Liepmann… - Biosensors and …, 2019 - Elsevier
Existing at the interface of biology and electronics, living cells have been in use as
biorecognition elements (bioreceptors) in biosensors since the early 1970s. They are an …
biorecognition elements (bioreceptors) in biosensors since the early 1970s. They are an …
[HTML][HTML] Seeing beyond the limit: A guide to choosing the right super-resolution microscopy technique
J Valli, A Garcia-Burgos, LM Rooney… - Journal of Biological …, 2021 - ASBMB
Super-resolution microscopy has become an increasingly popular and robust tool across the
life sciences to study minute cellular structures and processes. However, with the increasing …
life sciences to study minute cellular structures and processes. However, with the increasing …
[HTML][HTML] G protein–coupled receptor signaling: new insights define cellular nanodomains
G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …
family and are involved in the regulation of most cell functions. Most of them reside …
[HTML][HTML] Technological advances in super-resolution microscopy to study cellular processes
C Bond, AN Santiago-Ruiz, Q Tang, M Lakadamyali - Molecular Cell, 2022 - cell.com
Since its initial demonstration in 2000, far-field super-resolution light microscopy has
undergone tremendous technological developments. In parallel, these developments have …
undergone tremendous technological developments. In parallel, these developments have …
[HTML][HTML] Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
AB Santa Cruz Garcia, KP Schnur, AB Malik… - Nature …, 2022 - nature.com
Gasdermin D forms large,~ 21 nm diameter pores in the plasma membrane to drive the cell
death program pyroptosis. These pores are thought to be permanently open, and the …
death program pyroptosis. These pores are thought to be permanently open, and the …