STAT3 is an important transcription factor that regulates cell growth and proliferation by
regulating gene transcription of a plethora of genes. This protein also has many roles in …

Immune effector cells in the microenvironment tend to be depleted or remodeled, unable to
perform normal functions, and even promote the malignant characterization of tumors …

TNK1 is a non-receptor tyrosine kinase with poorly understood biological function and
regulation. Here, we identify TNK1 dependencies in primary human cancers. We also …

Blood disorders include a wide spectrum of blood-associated malignancies resulting from
inherited or acquired defects. The ineffectiveness of existing therapies against blood …

Simple Summary The Janus kinase-signal transducer and activator of transcription (JAK-
STAT) pathway is aberrantly activated in many malignancies. Inhibition of this pathway via …

Somatic mutations have a central role in cancer, but there are also a few rare autoimmune
diseases in which somatic mutations play a major role. We have recently shown that …

Myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential
thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal disorders complicated …

Simple Summary Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive blood cancer
with poor survival rates, particularly for patients with advanced-stage and relapsed disease …

Abstract Type T Large Granular Lymphocyte Leukemia (T-LGLL) is a chronic disorder
characterized by the abnormal proliferation of clonal cytotoxic T cells. The intriguing …

STAT3 mediates signalling downstream of cytokine and growth factor receptors where it acts
as a transcription factor for its target genes, including oncogenes and cell survival regulating …