Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this
work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure …

Premature ovarian insufficiency (POI) is clinically irreversible in women aged over 40 years.
Although numerous studies have demonstrated satisfactory outcomes of mesenchymal stem …

Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …

Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging
and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes …

Cisplatin‐(CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin.
Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin …

Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous
or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex …

Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal
ganglion cell (RGC) somas, degeneration of axons, and loss of synapses at dendrites and …