Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of
clinical features commonly known as Down syndrome (DS). DS is among the most …

Great strides have been made over the past 30 years in understanding the
neurodevelopmental changes underlying the intellectual disability (ID) in Down syndrome …

Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide
spectrum of neurodevelopmental outcomes. At present, the relationship between structural …

Human fetal brains show regionally different temporal patterns of sulcal emergence
following a regular timeline, which may be associated with spatiotemporal patterns of gene …

Pathogenic copy number variants (CNVs) and aneuploidies alter gene dosage and are
associated with neurodevelopmental psychiatric disorders such as autism spectrum disorder …

Those with Down syndrome (DS)—trisomy for chromosome 21—are routinely impacted by
cognitive dysfunction and behavioral challenges in children and adults and Alzheimer's …

The increased life expectancy of individuals with Down syndrome (DS) is associated with
increased prevalence of trisomy 21–linked early-onset Alzheimer's disease (EOAD) and …

Mouse models of Down syndrome (DS) have been invaluable tools for advancing
knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts …

Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated
with deviations in cortical development evidenced by simplified gyral appearance and …

Isolated cerebral ventriculomegaly (IVM) is the most common prenatally diagnosed brain
anomaly occurs in 0.2–1% of pregnancies. However, knowledge of fetal brain development …