Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Chemical modifications of histones can mediate diverse DNA-templated processes,
including gene transcription,–. Here we provide evidence for a class of histone post …

Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental
substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours …

Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

Mammalian SWI/SNF (mSWI/SNF) adenosine triphosphate–dependent chromatin
remodelers modulate genomic architecture and gene expression and are frequently mutated …

The recent torrent of structures of chromatin complexes determined by cryoelectron
microscopy provides an opportunity to discern general principles for how chromatin factors …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …