Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …

Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-
immunoglobulins and have been highly conserved during evolution. IgMs are initially …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicle for RNA
therapeutics, partly because of established lipid structure–activity relationships focused on …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a
major focus of COVID-19 research due to its clinical relevance and importance in vaccine …

Objective This study aimed to elucidate the presence, antigen specificities, and potential
clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a …