The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

The focus of this overview is on the animal models of obesity most commonly utilized in
research. The models include monogenic models in the leptin pathway, polygenic diet …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
involved in many cellular processes, including cell growth and differentiation, immune …

In addition to effects on appetite and metabolism, leptin influences many neuroendocrine
and physiological systems, including the sympathetic nervous system. Building on my Carl …

Leptin resistance refers to states in which leptin fails to promote its anticipated effects,
frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with …

Context: Appetite-related hormones may play an important role in weight regain after obesity
therapy. Objective: Our objective was to investigate the potential involvement of ghrelin …

Appetite and food intake are increased during pregnancy, comprising an adaptive response
that facilitates energy storage in preparation for the high metabolic demands of pregnancy …

The alarming increase in the incidence of obesity and obesity-associated disorders makes
the etiology of obesity a widely studied topic today. As opposed to 'homeostatic feeding' …

As we approach the end of two decades of leptin research, the comparative biology of leptin
is just beginning. We now have several leptin orthologs described from nearly every major …

Feeding a high-fat diet (HFD) to rabbits results in increased blood pressure and renal
sympathetic nerve activity (RSNA) and marked increases in plasma leptin and insulin. We …