The human stress response has evolved to maintain homeostasis under conditions of real or
perceived stress. This objective is achieved through autoregulatory neural and hormonal …

Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Objectives Previous studies on the pneumonia outbreak caused by the 2019 novel
coronavirus disease (COVID-19) were based on information from the general population …

Hepatitis B reactivation associated with immune-suppressive and biological therapies is
emerging to be an important cause of morbidity and mortality in patients with current or prior …

An autoimmune disease is defined as a clinical syndrome resulted from an instigation of
both T cell and B cell or individually, in the absence of any present infection or any sort of …

Background There is growing concern about individuals reported to suffer repeat COVID-19
disease episodes, these in a small number of cases characterised as de novo infections with …

In response to physiological and psychogenic stressors, the hypothalamic–pituitary–adrenal
(HPA) axis orchestrates the systemic release of glucocorticoids (GCs). By virtue of nearly …

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor
belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically …

Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in
thedeveloping and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …