Introduction: Exogenous IGF-1 protects the brain from ischemic injury and improves function.
However, its clinical application to neurological disorders is limited by its large molecular …

The concept that nature tends to reuse motifs and structural components is commonly
understood. In the case of proteins and peptides, common structural motifs such as helices …

Synthesis of the tetracyclic core skeleton of the lundurines by a gold-catalyzed cyclization -
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Neurodegenerative diseases of the central nervous system (CNS) pose a serious health
concern worldwide, with a particular incidence in developed countries as a result of life …

Rett syndrome (RTT) is rare neurodevelopmental disorder caused by mutations in the
MECP2 gene that encodes methyl-CpG-binding protein 2 (MeCP2), a DNA-binding protein …

Insulin‐like growth factor‐1 (IGF‐1) is neuroprotective and improves long‐term function after
brain injury. However, its clinical application to neurological disorders is limited by its large …

The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is
the tripeptide molecule Glypromate®(Gly–Pro–Glu). Glypromate® has demonstrated …

Addition of pentafluoroethyllithium to cyclic imines leads to pentafluoroethyl substituted
pyrrolidines, piperidines and azepanes while reaction of cyclic lactims gives rise to 2 …

The tripeptide glycine-proline-glutamate (GPE) is the naturally cleaved N-terminal tripeptide
of insulin-like growth factor-1 (IGF-1) in brain tissues by an acid protease. Although GPE …

This review describes available methods for the diastereoselective and asymmetric
synthesis of quaternary prolines. The focus is on the preparation of α‐functionalized prolines …