Tumor development and angiogenesis in adult brain tumor: glioblastoma

BK Ahir, HH Engelhard, SS Lakka - Molecular neurobiology, 2020 - Springer
Angiogenesis is the growth of new capillaries from the preexisting blood vessels.
Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on …

Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.

MS Tomar, A Kumar, C Srivastava… - Biochimica et Biophysica …, 2021 - Elsevier
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …

Short-course radiation plus temozolomide in elderly patients with glioblastoma

JR Perry, N Laperriere, CJ O'Callaghan… - … England Journal of …, 2017 - Mass Medical Soc
Background Glioblastoma is associated with a poor prognosis in the elderly. Survival has
been shown to increase among patients 70 years of age or younger when temozolomide …

The prognostic value of MGMT promoter methylation in glioblastoma: a meta‐analysis of clinical trials

MM Binabaj, A Bahrami, S ShahidSales… - Journal of cellular …, 2018 - Wiley Online Library
The DNA repair protein O6‐Methylguanine‐DNA methyltransferase (MGMT) is suggested to
be associated with resistance to alkylating agents such as Temozolomide which is being …

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly

G Reifenberger, B Hentschel, J Felsberg… - … journal of cancer, 2012 - Wiley Online Library
Abstract O6‐methylguanine‐DNA‐methyltransferase (MGMT) promoter methylation
identifies a subpopulation of glioblastoma patients with more favorable prognosis and …

Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma

G Cabrini, E Fabbri, CL Nigro… - International …, 2015 - spandidos-publications.com
O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear
protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the …

Optimal management of elderly patients with glioblastoma

N Laperriere, M Weller, R Stupp, JR Perry… - Cancer treatment …, 2013 - Elsevier
Median age at diagnosis in patients with glioblastoma (GB) is slowly increasing with an
aging population in Western countries, and was 64years in 2006. The number of patients …

Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial

JG Pérez-Larraya, F Ducray, O Chinot… - Journal of clinical …, 2011 - ascopubs.org
Purpose The management of glioblastoma multiforme (GBM) in elderly patients with poor
performance status is not well established. A trial evaluating the efficacy and safety of …

Prolonged survival in secondary glioblastoma following local injection of targeted alpha therapy with 213Bi-substance P analogue

L Krolicki, F Bruchertseifer, J Kunikowska… - European journal of …, 2018 - Springer
Background Glioblastoma multiforme (GBM), the most common malignant brain tumor,
mainly manifests as a primary de novo and less frequently as a secondary glial neoplasm …

Glioblastoma in elderly patients: current management and future perspectives

G Minniti, G Lombardi, S Paolini - Cancers, 2019 - mdpi.com
The incidence of glioblastoma (GBM) in the elderly population is slowly increasing in
Western countries. Current management includes surgery, radiation therapy (RT) and …