Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Glycans in the form of oligosaccharides, polysaccharides, and glycoconjugates are
ubiquitous in nature, and their structures range from linear assemblies to highly branched …

Glycan recognition by glycan‐binding proteins is central to the biology of all living
organisms. The efficient capture and characterization of relatively weak non‐covalent …

Carbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and
thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major …

Computer-aided drug design (CADD) approaches are playing an increasingly important role
in understanding the fundamentals of ligand-receptor interactions and helping medicinal …

Src homology‐2 domain‐containing protein tyrosine phosphatase‐2 (SHP2) is a key
regulatory factor in the cell cycle and its activating mutations play an important role in the …

Glycans are ubiquitous in nature, decorating our cells and serving as the initial points of
contact with any visiting entities. These glycan interactions are fundamental to host …

Fragment-based drug discovery is a powerful approach in drug discovery, applicable to a
wide range of targets. This method enables the discovery of potent compounds that can …

Meyerozyma guilliermondii is a rare yeast pathogen contributing to the deadly invasive
candidiasis. M. guilliermondii strain SO, as a promising protein expression host, showed …

Fragment-based lead discovery (FBLD) is a powerful application for developing ligands as
modulators of disease targets. This approach strategy involves identification of interactions …