microRNA dysregulation in neurodegenerative diseases: A systematic review
CA Juźwik, SS Drake, Y Zhang, N Paradis-Isler… - Progress in …, 2019 - Elsevier
While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …
pathological features and mechanisms contribute to neurodegeneration across diseases …
Dysregulated molecular pathways in amyotrophic lateral sclerosis–frontotemporal dementia spectrum disorder
FB Gao, S Almeida, R Lopez‐Gonzalez - The EMBO journal, 2017 - embopress.org
Frontotemporal dementia (FTD), the second most common form of dementia in people under
65 years of age, is characterized by progressive atrophy of the frontal and/or temporal lobes …
65 years of age, is characterized by progressive atrophy of the frontal and/or temporal lobes …
Poly (GR) in C9ORF72-related ALS/FTD compromises mitochondrial function and increases oxidative stress and DNA damage in iPSC-derived motor neurons
GGGGCC repeat expansions in C9ORF72 are the most common genetic cause of both ALS
and FTD. To uncover underlying pathogenic mechanisms, we found that DNA damage was …
and FTD. To uncover underlying pathogenic mechanisms, we found that DNA damage was …
C9ORF72-ALS/FTD-associated poly (GR) binds Atp5a1 and compromises mitochondrial function in vivo
SY Choi, R Lopez-Gonzalez, G Krishnan… - Nature …, 2019 - nature.com
The GGGGCC repeat expansion in C9ORF72 is the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, it is not …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, it is not …
Human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice
OM Peters, GT Cabrera, H Tran, TF Gendron… - Neuron, 2015 - cell.com
A non-coding hexanucleotide repeat expansion in the C9ORF72 gene is the most common
mutation associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
mutation associated with familial amyotrophic lateral sclerosis (ALS) and frontotemporal …
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …
(ALS). Here, through a combination of RNA-Seq and electrophysiological studies on …
The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
alternatives to classical monotarget therapies and microRNAs are of particular interest in …
Dysregulated mi RNA biogenesis downstream of cellular stress and ALS‐causing mutations: a new mechanism for ALS
Interest in RNA dysfunction in amyotrophic lateral sclerosis (ALS) recently aroused upon
discovering causative mutations in RNA‐binding protein genes. Here, we show that …
discovering causative mutations in RNA‐binding protein genes. Here, we show that …
Identification of microRNA-124-3p as a putative epigenetic signature of major depressive disorder
B Roy, M Dunbar, RC Shelton, Y Dwivedi - Neuropsychopharmacology, 2017 - nature.com
Major depressive disorder (MDD) is predicted to be the second leading cause of global
disease burden by 2030. A large number of MDD patients do not respond to the currently …
disease burden by 2030. A large number of MDD patients do not respond to the currently …
Neurotransmitter deficits from frontotemporal lobar degeneration
Frontotemporal lobar degeneration causes a spectrum of complex degenerative disorders
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …
including frontotemporal dementia, progressive supranuclear palsy and corticobasal …