Basic and clinical studies have continued to discover novel roles of the enterohepatic bile
acid signaling in regulation of key metabolic pathways. Such knowledge forms the molecular …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Modulating bile salt homeostasis has proven a promising treatment strategy in models of
cholestasis and are continuously being further developed. Confirmatory clinical studies are …

Cyp2c70 knockout mice lack the enzyme that produces muricholic acids and show a “human-
like” hydrophobic bile acid pool-induced hepatobiliary injury. In this study, we investigated …

Ethnopharmacological relevance: Pulsatilla decoction (PD) is a classical prescription for the
treatment of ulcerative colitis. Previous studies have demonstrated that the therapeutic …

The gut microbiota, a metabolic regulator, orchestrates the production of bioactive
metabolites such as secondary bile acids. Growing evidence suggests that shifts in the gut …