Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

Many environmental conditions can constrain the ability of animals to obtain sufficient food
energy, or transform that food energy into useful chemical forms. To survive extended …

All mammals and birds must develop effective strategies to cope with reduced oxygen
availability. These animals achieve tolerance to acute and chronic hypoxia by (a) reductions …

Many vertebrates are challenged by either chronic or acute episodes of low oxygen
availability in their natural environments. Brain function is especially vulnerable to the effects …

Rationale: Liver resection and transplantation surgeries are accompanied by hepatic
ischemia-reperfusion (HIR) injury that hampers the subsequent liver recovery. Given that the …

Torpor during hibernation defines the nadir of mammalian metabolism where whole animal
rates of metabolism are decreased to as low as 2% of basal metabolic rate. This capacity to …

Abstract The Oxidative Stress Theory of Aging has had tremendous impact in research
involving aging and age-associated diseases including those that affect the nervous system …

Hibernation evolved in some small mammals that live in cold environments, presumably to
conserve energy when food supplies are low. Throughout the winter, hibernators cycle …

Mammals that hibernate experience extreme metabolic states and body temperatures as
they transition between euthermia, a state resembling typical warm blooded mammals, and …

During hibernation, animals cycle between periods of torpor, during which body temperature
(Tb) and metabolic rate (MR) are suppressed for days, and interbout euthermia (IBE), during …