Thirty years ago, there was an emerging appreciation for the significance of oxidative stress
in newborn disease. This prompted a renewed interest in the impact of oxygen therapy for …

Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature,
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …

While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of
mitochondrial dynamics in angiogenesis, the formation of new blood vessels from existing …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Persistent pulmonary hypertension of the newborn (PPHN) is one of the main causes of
neonatal morbidity and mortality. It is characterized by sustained elevation of pulmonary …

Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

Pulmonary hypertension describes a heterogeneous disease defined by increased
pulmonary artery pressures, and progressive increase in pulmonary vascular resistance due …

Rationale: Endothelial AMP-activated protein kinase (AMPK) plays an important role for
vascular homeostasis, and its role is impaired by vascular inflammation. However, the role of …

The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery.
Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in …

In the present study, we investigated the influence of weaning on antioxidant status,
intestinal integrity, mitochondrial function, and the mitophagy level in piglets (weaned at 21 …