Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response
KY King, MA Goodell - Nature Reviews Immunology, 2011 - nature.com
Cells of the innate and adaptive immune systems are the progeny of a variety of
haematopoietic precursors, the most primitive of which is the haematopoietic stem cell …
haematopoietic precursors, the most primitive of which is the haematopoietic stem cell …
Inflammatory signals regulate hematopoietic stem cells
Hematopoietic stem cells (HSCs) are the progenitors of all blood and immune cells, yet their
role in immunity is not well understood. Most studies have focused on the ability of …
role in immunity is not well understood. Most studies have focused on the ability of …
[PDF][PDF] The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
T Hoyler, CSN Klose, A Souabni, A Turqueti-Neves… - Immunity, 2012 - cell.com
Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal
infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13 …
infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13 …
Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1
Targeted genome editing in hematopoietic stem/progenitor cells (HSPCs) is an attractive
strategy for treating immunohematological diseases. However, the limited efficiency of …
strategy for treating immunohematological diseases. However, the limited efficiency of …
[PDF][PDF] Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation
TYF Halim, A MacLaren, MT Romanish, MJ Gold… - Immunity, 2012 - cell.com
Natural helper (NH) cells are innate lymphoid cells (ILCs) that produce T helper-2 (Th2)-cell-
type cytokines in the lung-and gut-associated lymphoid tissues. Currently, the lineage …
type cytokines in the lung-and gut-associated lymphoid tissues. Currently, the lineage …
ILC1s control leukemia stem cell fate and limit development of AML
Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates
histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of …
histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of …
MicroRNA miR-125a controls hematopoietic stem cell number
S Guo, J Lu, R Schlanger, H Zhang… - Proceedings of the …, 2010 - National Acad Sciences
MicroRNAs influence hematopoietic differentiation, but little is known about their effects on
the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential …
the stem cell state. Here, we report that the microRNA processing enzyme Dicer is essential …
[HTML][HTML] Tissue-resident NK cells: development, maturation, and clinical relevance
E Hashemi, S Malarkannan - Cancers, 2020 - mdpi.com
Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in
killing infected or transformed cells. NK cells mediate their effector functions using non …
killing infected or transformed cells. NK cells mediate their effector functions using non …
Hematopoiesis in numbers
Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the~ 10
13 blood and immune cells distributed throughout the human body. We argue that a …
13 blood and immune cells distributed throughout the human body. We argue that a …