In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

The heterogenous subcellular distribution of a wide array of channels, pumps and
exchangers allows extracellular stimuli to induce increases in cytoplasmic Ca2+ …

Although the physiological relevance of mitochondrial Ca 2+ homeostasis is widely
accepted, no information is yet available on the molecular identity of the proteins involved in …

Mitochondria are dynamic organelles in cells. The control of mitochondrial motility by
signaling mechanisms and the significance of rapid changes in motility remains elusive. In …

Over recent years, it has become clear that mitochondria play a central role in many key
aspects of animal physiology and pathophysiology. Their central and ubiquitous task is …

Although it has been known for over three decades that mitochondria are endowed with a
complex array of Ca2+ transporters and that key enzymes of mitochondrial metabolism are …