The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Head and neck squamous cell carcinoma (HNSCC) arises through exposure to
environmental carcinogens or malignant transformation by human papillomavirus (HPV) …

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Tissue-resident macrophages are highly heterogeneous in terms of their functions and
phenotypes as a consequence of adaptation to different tissue environments. Local tissue …

The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Prosenescence therapy has recently emerged as a novel therapeutic approach for treating
cancer. However, this concept is challenged by conflicting evidence showing that the …