Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Immune interferon gamma (IFN-γ) is essential for mammalian host defense against
intracellular pathogens. IFN-γ induces nearly 2000 host genes, yet few have any assigned …

Cell-autonomous immunity is essential for host organisms to defend themselves against
invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune …

From plants to humans, the ability to control infection at the level of an individual cell—a
process termed cell-autonomous immunity—equates firmly with survival of the species …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

Intracellular pathogens pose a significant threat to animals. In defense, innate immune
sensors attempt to detect these pathogens using pattern recognition receptors that either …

Gene regulatory changes are thought to be major factors driving species evolution, with
creation of new regulatory regions likely being instrumental in contributing to diversity …

Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements,
their role in modulating cellular immune responses remains poorly understood. Using an …

Traditional views of the inflammasome highlight the assembly of pre-existing core
components shortly after infection or tissue damage. Emerging work, however, suggests that …