RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most
frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are …

Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

The major driver oncogenes MYC, mutant KRAS, and mutant TP53 often coexist and
cooperate to promote human neoplasia, which results in anticancer therapeutic …

Colorectal cancer (CRC) has a high degree of heterogeneity and identifying the genetic
information of individual tumor cells could help enhance our understanding of tumor biology …

Colorectal cancer represents the second leading cause of cancer-related death worldwide.
The therapeutic field of immuno-oncology has rapidly gained momentum, with strikingly …

Purpose The purpose of this study was to develop and validate a deep learning (DL)‐based
radiomics model to predict the response to chemotherapy in colorectal liver metastases …

Background Recently, the distinction between left-and right-sided colon cancer (LCC and
RCC) has been brought into focus. RCC is associated with an inferior overall survival and …

As one of the common cancers that threaten human life, the recurrence and metastasis of
colorectal cancer seriously affect the prognosis of patients. Although new drugs and …

Inflammatory microenvironment is an important factor for promoting cancer invasion and
metastasis, but the underlying molecular mechanisms remain unclear. Here, we mimicked …

While adjuvant chemotherapy is an established treatment for pathological stage II and
especially stage III colon cancer, its role in the multimodal management of rectal cancer …