The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP)
receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas …

Buprenorphine, an opioid with mixed agonist-antagonist activity at classical opioid
receptors, has been approved recently for the treatment of opioid dependency …

Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented
the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ …

Abstract Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized
in 1995. The generation of specific agonists, antagonists and receptor deficient mice and …

The isolation of an opioid receptor-related clone soon led to the isolation and
characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This …

Orphanin FQ (OFQ) is the endogenous agonist of the opioid receptor‐like receptor (ORL‐1).
It and its precursor, prepro‐OFQ, exhibit structural features suggestive of the opioid peptides …

Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP4). This new NC/OP4 receptor system belongs to …

The recently discovered neuropeptide orphanin FQ (OFQ), and its opioid receptor‐like
(ORL1) receptor, exhibit structural features suggestive of the μ, κ, and δ opioid systems. The …

Homology cloning and, more recently, the sequencing of whole genomes, have identified
many open reading frames encoding proteins of unknown function, in particular putative G …