[PDF][PDF] Hallmarks of response, resistance, and toxicity to immune checkpoint blockade
G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with
hormone action, thereby increasing the risk of adverse health outcomes, including cancer …
hormone action, thereby increasing the risk of adverse health outcomes, including cancer …
The exposome and health: Where chemistry meets biology
Despite extensive evidence showing that exposure to specific chemicals can lead to
disease, current research approaches and regulatory policies fail to address the chemical …
disease, current research approaches and regulatory policies fail to address the chemical …
Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
Frontiers in quantifying wildlife behavioural responses to chemical pollution
Animal behaviour is remarkably sensitive to disruption by chemical pollution, with
widespread implications for ecological and evolutionary processes in contaminated wildlife …
widespread implications for ecological and evolutionary processes in contaminated wildlife …
The contribution of the exposome to the burden of cardiovascular disease
Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …
the Global Burden of Disease project, indicate that chronic non-communicable diseases …
[HTML][HTML] Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
E Drakvik, R Altenburger, Y Aoki, T Backhaus… - Environment …, 2020 - Elsevier
The number of anthropogenic chemicals, manufactured, by-products, metabolites and
abiotically formed transformation products, counts to hundreds of thousands, at present …
abiotically formed transformation products, counts to hundreds of thousands, at present …
Prospects and challenges of multi-omics data integration in toxicology
S Canzler, J Schor, W Busch, K Schubert… - Archives of …, 2020 - Springer
Exposure of cells or organisms to chemicals can trigger a series of effects at the regulatory
pathway level, which involve changes of levels, interactions, and feedback loops of …
pathway level, which involve changes of levels, interactions, and feedback loops of …
Defining the scope of exposome studies and research needs from a multidisciplinary perspective
P Zhang, C Carlsten, R Chaleckis… - … science & technology …, 2021 - ACS Publications
The concept of the exposome was introduced over 15 years ago to reflect the important role
that the environment exerts on health and disease. While originally viewed as a call-to-arms …
that the environment exerts on health and disease. While originally viewed as a call-to-arms …
Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
SK Bopp, A Kienzler, AN Richarz… - Critical Reviews in …, 2019 - Taylor & Francis
This paper summarizes current challenges, the potential use of novel scientific
methodologies, and ways forward in the risk assessment and risk management of mixtures …
methodologies, and ways forward in the risk assessment and risk management of mixtures …